Seco Rapamycin (sodium salt)

Seco Rapamycin (sodium salt)

CAT N°: 16158
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From 177.00 150.45

Rapamycin (Item No. 13346) is a natural macrolide immunosuppressant that activates mTORC1. Seco rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. 13346) resulting from ester hydration followed by dehydration.{26501} It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay.{26501} Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells.{26499} Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species.{26500} While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.{26502}

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