SD 169

SD 169

CAT N°: 14156
Price:

55.00 46.75

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38? (IC50 = 3.2 nM) and p38? (IC50 = 122 nM).{22220} It has no inhibitory effect against a panel of other kinases, including p38? MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 ?M.{22220} SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg.{22220} In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis.{22220} SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.{22221}

We also advise you

TAF 10 Peptide

TAF 10 Peptide

TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity.{16903} One vial of this peptide...

€191.00
View