SD-1029

SD-1029

CAT N°: 21029
Price:

From 48.00 40.80

SD-1029 is a Janus kinase 2 (JAK2) inhibitor.{48790,48791} It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 ?M and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 ?M.{48790} SD-1029 (10 ?M) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells.{48790} It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 ?M.{48792} SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.{48791}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide
  • Correlated keywords
    • 118372-38-6 SD1029 JAK 2 1 MDAMB468 MDAMB MB468 OVCAR 8TR 8 TR OVCAR8 SKOV 3TR SKOV3 IL6 STAT 3 BHK21 U2 OS SNU387 SNU398 Hep G2 Huh 7 GL 37
  • Product Overview:
    SD-1029 is a Janus kinase 2 (JAK2) inhibitor.{48790,48791} It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 ?M and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 ?M.{48790} SD-1029 (10 ?M) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells.{48790} It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 ?M.{48792} SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.{48791}

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