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scyllo-Inositol is a stereoisomer of inositol. It induces a structural transition in amyloid-? (1-42) (A?42), but not A?40, from a random coil to ?-sheet structure but prevents A?42 fibril formation in cell-free assays.{52735} scyllo-Inositol reduces A?40- and A?42-induced decreases in the survival of PC12 cells. It reduces increases in soluble and insoluble brain A?40 and A?42 levels in four- and six-month-old mice in the TgCRND8 model of Alzheimer’s disease when administered starting at six weeks of age, which is prior to the onset of increased A? levels and spatial learning deficits.{52736} It also reduces increases in insoluble brain A?40 and A?42 levels in six-month-old mice when administered starting at five months of age when the neuropathological and learning deficits are already established. scyllo-Inositol improves established spatial learning and memory deficits in the Morris water maze when compared with TgCRND8 control and non-transgenic littermate control mice. It also improves survival of TgCRND8 mice.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 100 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 488-59-5 |
| Molecular formula | C6H12O6 |
| Smiles | O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O |
| Molecular weight | 180,2 |
| Custom code | 2906.13 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
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