Sclareolide

Sclareolide

CAT N°: 31371
Price:

From 48.00 40.80

Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 ?g/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 ?M).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 ?M).{57258} Sclareolide (5, 10, and 20 ?M) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (3aR,5aS,9aS,9bR)-decahydro-3a,6,6,9a-tetramethyl-naphtho[2,1-b]furan-2(1H)-one
  • Correlated keywords
    • Botrytis Cochliobolus Fusarium Alternaria HEK293 T HEK 293T NO BV2 PANC1 AsPC1
  • Product Overview:
    Sclareolide is a sesquiterpene lactone that has been found in Salvia and has diverse biological activities.{57254,57255,57257,57258} It inhibits mycelial growth in the phytopathogenic fungi B. cinerea, F. coeruleum, C. lunata, F. graminearum, and A. brassicae by 33.93, 67.14, 27.04, 46.22, and 32.48%, respectively, when used at a concentration of 100 ?g/ml.{57255} Sclareolide is an Ebola virus entry inhibitor that reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with Ebola virus glycoprotein (EC50 = 8 ?M).{57257} It inhibits nitric oxide production in LPS-stimulated BV-2 cells (IC50 = 20.3 ?M).{57258} Sclareolide (5, 10, and 20 ?M) enhances gemcitabine-induced cell death in gemcitabine-resistant PANC-1 and AsPC-1 human pancreatic cancer cells.{57254}

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