SCH 39166 (hydro<wbr/>bromide)

SCH 39166 (hydrobromide)

CAT N°: 25331
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From 60.00 51.00

SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 11-chloro-7-methyl-6,6?S,7,8,9,13?R-hexahydro-5H-benzo[d]naphtho[2,1-?]azepin-12-ol, monohydrobromide
  • Correlated keywords
    • 112108-00-6 SCH39166
  • Product Overview:
    SCH 39166 is a dopamine D1 receptor antagonist (Ki = 5 nM).{39925} It is selective for D1 over D2-4 receptors (Kis = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D5 receptors (Ki = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED50 = 0.84 mg/kg).{39926} It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake.{39927} SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.{39928}

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