SC-<wbr/>66

SC-66

CAT N°: 10876
Price:

From 57.00 48.45

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2).{13740} Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer.{15097} Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt.{19437} At 4 ?g/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death.{19437} In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.{19437}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2E,6E-bis(4-pyridinylmethylene)-cyclohexanone
  • Correlated keywords
    • SC66 SC 66 analogs cyclohexanone curcumin cancers Akts inhibitors inhibits inhibition cancers ubiquitination cells death tumors tumorigenesis
  • Product Overview:
    Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2).{13740} Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer.{15097} Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt.{19437} At 4 ?g/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death.{19437} In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.{19437}

We also advise you