SC-<wbr/>51089

SC-51089

CAT N°: 10011561
Price:

From 34.00 28.90

The prostaglandin E2 (PGE2) receptor EP1 is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51089 is a selective EP1 antagonist, first shown to have in vivo analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in the rat.{17835,17836} SC-51089 also inhibits the growth of glioma cell lines in vitro (IC50 = ~1 ?M) and slows tumor growth in vivo.{17837} In addition, SC-51089 is neuroprotective, attenuating neuronal cell death in response to oxidative stress, an effect that is also found in EP1-/- mice and mediated by PGE2.{15975,17838}

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