Sauchinone

Sauchinone

CAT N°: 19577
Price:

From 48.00 40.80

Sauchinone is a lignan that has been found in S. chinensis and has diverse biological activities.{12537,31525,57256,31526} It inhibits LPS-induced expression of the genes encoding inducible nitric oxide synthase (iNOS), TNF-?, and COX-2 (IC50s = ?10 µM for all), as well as LPS-induced activation of NF-?B and nuclear translocation of NF-?B p65 in RAW 264.7 cells.{12567} Sauchinone reduces hydrogen peroxide-induced increases in heat shock protein 70 (Hsp70) levels and cell death in C2C12 mouse skeletal muscle myoblasts.{31525} In vivo, sauchinone (10 and 30 mg/kg) reduces hepatic formation of thiobarbituric acid reactive substances (TBARS), plasma levels of alanine aminotransferase (ALT), and hepatocyte cell death in a mouse model of iron overload-induced liver injury.{57256} Sauchinone (10 mg/kg) reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury.{31526}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4′,5′-g]xanthen-5-one
  • Correlated keywords
    • antiinflammatory lignan lignin antiangiogenic antinociceptive cardioprotective HO-1 HO1 Schisandra NF?B NF-kB NFkB Schisandra TNF? COX2 NF?B p 65 Hsp
  • Product Overview:
    Sauchinone is a lignan that has been found in S. chinensis and has diverse biological activities.{12537,31525,57256,31526} It inhibits LPS-induced expression of the genes encoding inducible nitric oxide synthase (iNOS), TNF-?, and COX-2 (IC50s = ?10 µM for all), as well as LPS-induced activation of NF-?B and nuclear translocation of NF-?B p65 in RAW 264.7 cells.{12567} Sauchinone reduces hydrogen peroxide-induced increases in heat shock protein 70 (Hsp70) levels and cell death in C2C12 mouse skeletal muscle myoblasts.{31525} In vivo, sauchinone (10 and 30 mg/kg) reduces hepatic formation of thiobarbituric acid reactive substances (TBARS), plasma levels of alanine aminotransferase (ALT), and hepatocyte cell death in a mouse model of iron overload-induced liver injury.{57256} Sauchinone (10 mg/kg) reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury.{31526}

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