SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (human IgG1 Fc-tagged)

Territorial Availability: Available through Bertin Technologies only in France

• Correlated keywords
  • corona virus COVID-19 COVID19 2019-nCoV CoV2 SARSCoV2 S 1 ACE
• Product Overview:
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface glycoprotein receptor binding domain is a fragment of the SARS-CoV-2 surface glycoprotein, also known as the spike glycoprotein, which is a viral structural protein encoded by the S gene in SARS-CoV-2 RNA.{53462} It contains amino acids 319-541 of the full-length SARS-CoV-2 spike glycoprotein sequence. SARS-CoV-2 is a member of the Betacoronavirus genus of viruses and has 88% sequence identity with two bat-derived SARS-like CoVs.{53459} The SARS-CoV-2 genome contains approximately 30 kilobases that encode four structural proteins: spike, envelope, membrane, and nucleocapsid.{53462,49555} The spike protein of SARS-CoV-2 and the related viruses SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) is a transmembrane glycoprotein that assembles into homotrimers on the virus surface and is comprised of an N-terminal S1 subunit, which contains the receptor binding domain (RBD), and a C-terminal S2 subunit, which facilitates fusion between viral and host cell membranes.{46767,46768,49561} The 193-amino acid RBD of the SARS-CoV spike protein is a target for neutralizing antibodies.{46768,49525} The SARS-CoV-2 RBD, which spans amino acid residues 329 to 521, is 73% identical to that of SARS-CoV and can bind to human angiotensin-converting enzyme 2 (ACE2), which is the host cell surface receptor for both SARS-CoV and SARS-CoV-2.{46767,49525,49561} SARS-CoV-2 is the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53461,55257,55258} Cayman’s SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain protein can be used as an antigen or for Western blot, ELISA, protein-protein interaction studies, and other in vitro binding and in vivo functional assays.