SARS-CoV-2 Spike Glycoprotein (433-506)

CAT N°: 30430
Price:

2,586.00 2,198.10

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface glycoprotein (433-506) is a fragment of the SARS-CoV-2 surface glycoprotein, also known as the spike glycoprotein, encoded by the S gene in SARS-CoV-2 RNA.{53462} It contains amino acids 433-506 of the full-length SARS-CoV-2 spike glycoprotein sequence. SARS-CoV-2 is a member of the Betacoronavirus genus of viruses and has 88% sequence identity with two bat-derived SARS-like CoVs.{53459} The SARS-CoV-2 genome contains approximately 30 kilobases that encode four structural proteins: spike, envelope, membrane, and nucleocapsid.{53462,49555} The SARS-CoV-2 spike glycoprotein is located on the outer envelope of the virion and is comprised of an S1 and S2 subunit divided by a furin S-cleavage site not found in other SARS-CoVs.{46767,49561} The S1 subunit contains the N-terminus and a receptor binding domain (RBD; Item No. 30429), and the S2 subunit contains a fusion peptide, two heptad repeats, and the C-terminal domain.{46767} SARS-CoV-2 is the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53461,55257,55258} Cayman’s SARS-CoV-2 Spike Glycoprotein (433-506) contains the SARS-CoV-2 receptor binding motif (Item No. 30428) and a disulfide bridge between Cys480 and Cys488.

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