Sardomozide (hydro<wbr/>chloride)

Sardomozide (hydrochloride)

CAT N°: 34901
Price:

From 158.00 134.30

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), an enzyme involved in polyamine biosynthesis (IC50 = 0.005 µM for the rat liver enzyme).{61691} It is selective for SAMDC over diamine oxidase (DAO; IC50 = 18 µM for the rat small intestine enzyme). Sardomozide inhibits the proliferation of T24 bladder cancer cells (IC50 = 0.71 µM). It decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 murine leukemia cells when used at a concentration of 3 µM.{61692} Sardomozide (0.2 and 0.4 µM) inhibits HIV-1 replication in PM1 cells.{61693} It reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model when administered at doses of 0.5 and 5 mg/kg.{61692}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-hydrazinecarboximidamide, dihydrochloride
  • Correlated keywords
    • 149400-88-4 CGP48664 SAM-486A SAM486-A SAM-486-A T-24 L-1210 PM-1 SK-MEL24 SKMEL-24 SKMEL24
  • Product Overview:
    Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), an enzyme involved in polyamine biosynthesis (IC50 = 0.005 µM for the rat liver enzyme).{61691} It is selective for SAMDC over diamine oxidase (DAO; IC50 = 18 µM for the rat small intestine enzyme). Sardomozide inhibits the proliferation of T24 bladder cancer cells (IC50 = 0.71 µM). It decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 murine leukemia cells when used at a concentration of 3 µM.{61692} Sardomozide (0.2 and 0.4 µM) inhibits HIV-1 replication in PM1 cells.{61693} It reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model when administered at doses of 0.5 and 5 mg/kg.{61692}

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