Sarcosine

Sarcosine

CAT N°: 26799
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48.00 40.80

Sarcosine is an intermediate in the biosynthesis of glycine from choline.{48332} It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters.{48333} Sarcosine levels are increased in prostate cancer cell lines with an invasive phenotype compared with non-invasive cell lines.{48334} Sarcosine increases in a progressive fashion in prostate cancer with 0, 42, and 79% of benign, localized, and metastatic prostate tissue samples containing increased levels of sarcosine.

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