S3I-201

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 2-hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid
• Correlated keywords
  • STAT3 inhibitors inhibits inhibitions VI STAT transcriptions factors TFs vasculars diseases hypertension cardiac hearts hypertrophy S3I201 S3I 201 STATs STAT-3 3 activations active activators dimerizations genes IL-6 ILs 6 IL6 interleukins T-cells T cells angiotensin II oxidative stress endothelial dysfunctions collagen in vitro NSCs 74859 NSC-74859 NSC74859 signals transducers cytoplasms cytoplasmic cells membranes nucleus humans tumors upstream tyrosines kinases types 1 AT1 ATs receptors inflammatory mediators suppresses suppressions phosphorylations biosynthesis atrial natriuretic b-myosins beta-myosin .beta.-myosin ?-myosin heavy chains models
• Product Overview:
  Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} STAT signaling is also suspected to play a role in vascular disease since it can be activated through angiotensin II type 1 receptors or the inflammatory mediator interleukin (IL)-6.{23262} S3I-201 is an inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription. It can suppress IL-6-induced phosphorylation of STAT3 in T cells with an IC50 value of 38 ?M.{23263} Inhibiting STAT3 activation with 10 ?M S3I-201 was demonstrated to be protective against angiotensin II-induced oxidative stress, endothelial dysfunction, and hypertension in two different models of vascular disease.{23262} At 10 ?M, S3I-201 has also been used as a means to regress cardiac hypertrophy by inhibiting collagen biosynthesis and decreasing atrial natriuretic factor and ?-myosin heavy chain in an in vitro model.{23264}