€505.00 €429.25
S100 calcium-binding protein A1 (S100A1) is a calcium-binding protein that exists as a homodimer, with each subunit containing two EF-hand calcium-binding domains connected by a hinge region and a C-terminal extension.{60402} It is expressed primarily in ventricular cardiomyocytes but also in skeletal muscle and vascular endothelial cells.{60402,60404} In cardiomyocytes it is localized to the sarcoplasmic reticulum, mitochondria, and myofilaments where it regulates calcium homeostasis, contractile machinery, and cellular energy metabolism. S100A1 is localized to the cytoplasm with perinuclear enrichment in micro- and macrovascular endothelial cells and regulates responses to adrenergic receptor activation, vessel relaxation, and angiogenesis.{60404,60403} Overexpression of S100A1 is protective against the development of heart failure in post-ischemic isolated mouse cardiomyocytes and reduces mortality in a mouse model of myocardial infarction.{60403} S100A1 knockdown impairs post-ischemic angiogenesis and neovascularization in mice.{60404} S100A1 levels are inversely correlated with disease severity in patients with heart failure. Cayman’s S100A1 (human, recombinant) protein can be used for binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, composed of S100A1 (amino acids 2-94) fused to human IgG1 Fc at its C-terminus, consists of 330 amino acids and has a calculated molecular weight of 37.1 kDa. As a result of glycosylation, the monomer migrates at 40 kDa by SDS-PAGE under reducing conditions.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | Lyophilized from sterile 50 mM Tris, pH 7.5, with 100 mM glycine and 10 mM sodium chloride |
| Purity | ≥95% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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