(S)-<wbr/>(+)-<wbr/>Linoleyl-<wbr/>2'-<wbr/>Hydroxy-<wbr/>1'-<wbr/>Propylamide

(S)-(+)-Linoleyl-2′-Hydroxy-1′-Propylamide

CAT N°: 9001235
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From 122.00 103.70

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 ?M for CB1, CB2, respectively) and inhibits voltage-gated K+ channels.{7422,13859} LOEA also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 ?M) and is hydrolyzed by FAAH.{7251,3922} (S)-(+)-Linoleyl-2′-hydroxy-1′-propylamide is a homolog of LOEA, characterized by the addition of an (S)-?-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-2 methanandamide (Item No. 90076) imparts higher affinity for the CB receptor.{1092} The physiological actions of this compound have not been evaluated.

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