(S)-Ibuprofen

(S)-Ibuprofen

CAT N°: 16793
Price:

From €37.00 €31.45

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, µM, respectively).{1286} It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.{27415,27418} (S)-Ibuprofen also inhibits activation of NF-?B more effectively than (R)-ibuprofen (IC50s = 62 and 122 µM, respectively).{6935} However, the enantiomers are equipotent in blocking superoxide formation, ?-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 µM).{27418} A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.{27417,1208,27416}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • ?S-methyl-4-(2-methylpropyl)-benzeneacetic acid
  • Correlated keywords
    • biochemicals inflammation inhibitor NSAIDs cyclooxygenase enantiomer R ibuprofen COX activity NF-?B dexibuprofen nyfen s-optifen seractil ultraprofen d-ibuprofen 3Cl-5OH-BA
  • Product Overview:
    Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, µM, respectively).{1286} It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.{27415,27418} (S)-Ibuprofen also inhibits activation of NF-?B more effectively than (R)-ibuprofen (IC50s = 62 and 122 µM, respectively).{6935} However, the enantiomers are equipotent in blocking superoxide formation, ?-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 µM).{27418} A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.{27417,1208,27416}

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