(S)-<wbr/>Bromoenol lactone

(S)-Bromoenol lactone

CAT N°: 10006801
Price:

From 48.00 40.80

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase ? (iPLA2?) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2? versus iPLA2?.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl)-2H-pyran-2-one
  • Correlated keywords
    • selective iPLA2 inhibitors phospholipases PLAs BEL iPLA2b iPLA2.beta. iPLA2g iPLA2.gamma. lipids hydrolases cells signaling digestion membrane remodeling venom calcium independent releases AA arachidonic acids physiologic stimuli irreversible chiral mechanism-based vasopression-induced rat aortic smooth muscle A10
  • Product Overview:
    The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase ? (iPLA2?) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2? versus iPLA2?.

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