S-<wbr/>(5'-<wbr/>Adenosyl)-<wbr/>L-<wbr/>methionine chloride (hydro<wbr>chloride)

S-(5′-Adenosyl)-L-methionine chloride (hydrochloride)

CAT N°: 13956
Price:

From 62.00 52.70

S-(5′-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.{19419,16924,16845} The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine (Item No. 13603).{16924} SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine.{16924} Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-adenosine, dihydrochloride
  • Correlated keywords
    • 485-80-3 methyl donor methyltransferases epigenetics metabolism polyamines spermidine spermine AdoMet SAM SAM-binding proteins epigenetics histones modification chromatin remodeling genes regulations
  • Product Overview:
    S-(5′-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.{19419,16924,16845} The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine (Item No. 13603).{16924} SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine.{16924} Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.

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