S-(1,2-Dichlorovinyl)-Cysteine (hydrochloride)

S-(1,2-Dichlorovinyl)-Cysteine (hydrochloride)

CAT N°: 33894
Price:

From 274.00 232.90

S-(1,2-Dichlorovinyl)-cysteine is a nephrotoxin and metabolite of trichloroethylene.{61808,61809,61810} It is formed via a dichlorovinyl glutathione intermediate and its subsequent cleavage by dipeptidase.{61808} S-(1,2-Dichlorovinyl)-cysteine (1 mM) is cytotoxic to isolated human renal proximal tubule cells. It increases urine levels of N-acetyl-?-D-glucosaminidase, total protein, and glucose in rabbits when administered at a dose of 10 mg/kg.{61809} S-(1,2-Dichlorovinyl)-cysteine induces renal necrosis and lethality in rats (LD50s = 66-83 mg/kg).{61810}

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