(R,S)-Anatabine (tartrate)

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 1,2,3,6-tetrahydro-2,3′-bipyridine 2,3-dihydroxysuccinate
• Correlated keywords
  • 2743-90-0 175441-86-8 1335287-67-6 inhibitors intracellulars signaling alzheimer’s alzheimers diseases inflammation neurosciences alkaloids plants solanaceae tobacco urines nicotine gum patches inhalers medications locomotor reductions reduces amyloid beta A? A.beta. Abeta Ab production in vitro vivo ?-secretase ? secretase beta-secretase beta NF-?B NF ?B .kappa.B kappaB
• Product Overview:
  (R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana).{20193} It is an agonist of ?4?2 and ?6/?3?2?4 subunit-containing nicotinic acetylcholine receptors (nAChRs; EC50s = 6.1 and 3.6 µM, respectively). It is selective for ?4?2 and ?6/?3?2?4 subunit-containing nAChRs over ?3?4 subunit-containing nAChRs and ?7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively).{69082} (R,S)-Anatabine stimulates dopamine, but not norepinephrine, release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively). It increases the time spent at the top of the tank in a novel tank test, indicating anxiolytic-like activity, in zebrafish when used at a concentration of 10 mg/L. (R,S)-Anatabine (0.05 mg/ml in the drinking water) decreases disease severity in a mouse model of moderate, but not low or severe, experimental autoimmune thyroiditis induced by immunization with thyroglobulin, complete Freund’s adjuvant (CFA), and M. tuberculosis.{69083} It decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively).{69084} (R,S)-Anatabine has been used as a biomarker of tobacco use.{20195,20196}