Ro 60-0175

Ro 60-0175

CAT N°: 29520
Price:

From €48.00 €40.80

Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively).{52211} It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = ?1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, ?1-, ?2-, and ?1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and ?-, ?-, and ?-opioid receptors (IC50s = >1,000 nM), but does bind to ?2-adrenergic receptors (IC50 = 251 nM). {52212} In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 (Item No. 10096) or the 5-HT2A antagonist MDL 100,907 (volinanserin; Item No. 15936).{52213}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (?S)-6-chloro-5-fluoro-?-methyl-1H-indole-1-ethanamine, (2E)-2-butenedioate
  • Correlated keywords
    • 169675-08-5 600175 5HT 5HT2 CHOK1 H2H3 D2 D3 D4 D5 M2 M3 M4 M5 pro lactin volinan serin OR35030 ORG 35030
  • Product Overview:
    Ro 60-0175 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2 that stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A, 5-HT2B, and 5-HT2C receptors (EC50s = 447, 0.9, and 32 nM, respectively).{52211} It is selective for human 5-HT2A and 5-HT2C (Kis = 32 and 1 nM, respectively) over human 5-HT1A, 5-HT1D, 5-HT6, and 5-HT7, rat 5-HT1B and 5-HT3, and guinea pig 5-HT4 receptors (Kis = ?1,995 nM), as well as adenosine A1 and A2, histamine H1-3, dopamine D1-5, ?1-, ?2-, and ?1-adrenergic, M1-5 muscarinic, nicotinic, kainate, AMPA, and ?-, ?-, and ?-opioid receptors (IC50s = >1,000 nM), but does bind to ?2-adrenergic receptors (IC50 = 251 nM). {52212} In vivo, Ro 60-0175 increases plasma levels of corticosterone, oxytocin, and prolactin in rats (ED50s = 2.43, 4.19, and 4.03 mg/kg, respectively), effects that are not inhibited by the 5-HT2C antagonist SB-242084 (Item No. 10096) or the 5-HT2A antagonist MDL 100,907 (volinanserin; Item No. 15936).{52213}

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