Rifabutin-d<sub>7</sub>

Rifabutin-d7

CAT N°: 28904
Price:

688.00 584.80

Rifabutin-d7 is intended for use as an internal standard for the quantification of rifabutin (Item No. 16468) by GC- or LC-MS. Rifabutin is a rifamycin antibiotic.{62595,27023} It is active against a variety of Gram-positive and Gram-negative bacteria, including 81 clinical isolates of H. pylori (MIC50 = 0.25 µg/ml), as well as S. aureus, S. pyogenes, and C. trachomatis (MICs = 0.004, 0.005, and ~0.008 µg/ml, respectively). Rifabutin (0.5 µg/ml) is also active against 302 strains of M. tuberculosis.{27023} It inhibits protein synthesis via inhibition of DNA-dependent RNA polymerase (RNAP) activity.{27023} Rifabutin (10, 20, or 40 mg/kg) reduces the number of spleen, lung, and liver colony forming units (CFUs) in mouse models of disseminated Mycobacterium avium complex (MAC) infection.{62596} Formulations containing rifabutin have been used in the treatment of H. pylori infection.

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