Resolvin D2-d₅

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21’,22,22,22-d5 docosahexaenoic acid
• Correlated keywords
  • LC-MS LC/MS GC-MS GC/MS mass spectrometry MS deuterateds deuteriums EPA DHA inflammation anti-inflammatory antiinflammatory immune responses sepsis Docosahexaenoic Acid 4,7,10,13,16,19-(Z,Z,Z,Z,Z,E-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-(All-Z-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-Isomer Docosahexaenoic Acid 3,6,9,12,15,18-Isomer Docosahexaenoic Acid Dimer (All-Z Isomer) Docosahexaenoic Acid (All-Z Isomer) Acids Docosahexaenoic Docosahexaenoic Acids Acids Docosahexenoic Docosahexenoic Acids Docosahexaenoic Acid Docosahexaenoate 10007848
• Product Overview:
  Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209}