Regorafenib N-oxide

Regorafenib N-oxide

CAT N°: 35101
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From 48.00 40.80

Regorafenib N-oxide is an active metabolite of the multi-kinase inhibitor regorafenib (Item No. 18498).{58736} It is formed from regorafenib by the cytochrome P450 (CYP) isoform CYP3A4. Regorafenib N-oxide inhibits VEGFR2, Tie2, c-Kit, and B-RAF in vitro, as well as inhibits tumor growth in HT-29 and MDA-MB-231 mouse xenograft models when administered at a dose of 1 mg/kg.{58735}

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