Raloxifene 4'-Glu<wbr/>curonide

Raloxifene 4′-Glucuronide

CAT N°: 27831
Price:

598.00 508.30

Raloxifene 4’-glucuronide is a metabolite of the selective estrogen receptor modulator raloxifene (Item No. 10011620).{42731} It is formed from raloxifene via the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A8, and UGT1A10.{42732} It binds to the estrogen receptor with an IC50 value of 370 nM.{42731} Raloxifene 4’-glucuronide inhibits the voltage-gated potassium channel Kv4.3 by 6.2 and 20.1% when used at concentrations of 10 and 30 µM, respectively.{42733}

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