(R)-<wbr/>Flurbiprofen

(R)-Flurbiprofen

CAT N°: 70255
Price:

From €48.00 €40.80

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Item No. 70250) that has diverse biological activities.{16203,16204,16205,39781} It inhibits ?-secretase activity in vitro and, in vivo, it reduces formation of amyloid-? peptide 1-42 (A?42) and improves axonal transport in young A?-plaque free mice but not old mice with existing A? plaques in the Tg2576 transgenic model of Alzheimer’s disease.{16203,39781} (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-?B and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg.{16204} It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.{16205,16204}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (R)-(-)-2-fluoro-?-methyl-4-biphenylacetic acid
  • Correlated keywords
    • cyclooxygenases inhibitors NSAIDs COX-1 COX-2 nonsteroidal anti-inflammatory drugs cox1 cox2 pghs1 pghs2 pghs-1 pghs-2 prostaglandin H synthases synthase-1 synthase-2 inhibits inhibition neurochemistry
  • Product Overview:
    (R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Item No. 70250) that has diverse biological activities.{16203,16204,16205,39781} It inhibits ?-secretase activity in vitro and, in vivo, it reduces formation of amyloid-? peptide 1-42 (A?42) and improves axonal transport in young A?-plaque free mice but not old mice with existing A? plaques in the Tg2576 transgenic model of Alzheimer’s disease.{16203,39781} (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-?B and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg.{16204} It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.{16205,16204}

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