24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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Quinidine is a stereoisomer of the antimalarial agent quinine (Item No. 23958) and a class Ia antiarrhythmic agent.{37790,37791} Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner.{37790} It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes.{37792} It inhibits KKr, peak INa, and late INa (IC50s = 4.5, 11, and 12 µM, respectively) and can induce torsade de pointes in isolated rabbit hearts when used at a concentration of 1 µM.{37791} Quinidine induces QT prolongation in dogs.{37793} It also binds to M2 muscarinic acetylcholine receptors (Ki = 7.5 µM for human recombinant receptors expressed in HM2-B10 cells).{37794} Formulations containing quinidine have been used in the treatment of atrial fibrillation and ventricular arrhythmias.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 g, 25 g, 5 g, 50 g |
|---|---|
| Shipping | dry ice |
| CAS number | 56-54-2 |
| Molecular formula | C20H24N2O2 |
| Smiles | COC1=CC=C2C(C([C@H](O)[C@@]3([H])C[C@H]4[C@@H](C=C)C[N@@]3CC4)=CC=N2)=C1 |
| Molecular weight | 324,4 |
| Custom code | 2933.49 |
| Formulation | A crystalline solid |
| Purity | ≥95% (may contain up to 15% hydroquinidine) |
| UNSPSC code | 12352100 |
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