Pyronaridine (phosphate)

Pyronaridine (phosphate)

CAT N°: 16139
Price:

From 102.00 86.70

Pyronaridine is an antimalarial agent.{65123} It is active against six P. falciparum drug-sensitive or -resistant strains (IC50s = 1.53-3.94 nM). Pyronaridine (3, 6, and 8 mg/kg) in combination with artesunate (Item No. 11817) reduces parasitemia in P. chabaudi-infected mice. It inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected A459 cells overexpressing angiotensin-converting enzyme 2 (ACE2; IC50 = 198 nM).{65124} Pyronaridine is also cytotoxic against a panel of human cancer cells lines, including breast, ovarian, and lung cancer cells, with 50% cytotoxic concentration values (CC50s) ranging from 1.6 to 9.4 µM.{65125} Formulations containing pyronaridine have been used in the treatment of malaria.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-phenol, tetraphosphate
  • Correlated keywords
    • 7664-38-2 74847-35-1 anti-malarial SARSCoV2 covid19 coronavirus SARSCoV A-459 ACE-2 Plasmodium
  • Product Overview:
    Pyronaridine is an antimalarial agent.{65123} It is active against six P. falciparum drug-sensitive or -resistant strains (IC50s = 1.53-3.94 nM). Pyronaridine (3, 6, and 8 mg/kg) in combination with artesunate (Item No. 11817) reduces parasitemia in P. chabaudi-infected mice. It inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected A459 cells overexpressing angiotensin-converting enzyme 2 (ACE2; IC50 = 198 nM).{65124} Pyronaridine is also cytotoxic against a panel of human cancer cells lines, including breast, ovarian, and lung cancer cells, with 50% cytotoxic concentration values (CC50s) ranging from 1.6 to 9.4 µM.{65125} Formulations containing pyronaridine have been used in the treatment of malaria.

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