Pyrimethamine

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 5,4-chlorophenyl-6-ethyl-2,4-pyrimidinediamine
• Correlated keywords
  • antimalarial antiprotozoal anti-protozoal anti protozoal enzymes dihydrofolates reductases DHFRs inhibitors tetrahydrofolic acids folates pathways SOD1s superoxide dismutases 1s amyotrophic laterals sclerosis ALS infectious diseases biochemicals P falciparum Plasmodium Pfalciparum blocking blocks blockers activity activities prevents preventions productions coenzymes DNAs RNAs synthesis in vivo mouse models prophylactics effects sulphonamides synergistically synergistic arresting arrests arrested limits limited expressions genes BWs 50-63 BW50-63 5063 4753 RP 4753RP 4753-RP RP-4753 RP4753 Chloridine Chloridine Darachlor Daraprime Diaminopyritamin Erbaprelina Malacid Malocid Malocide NSCs 3061 NSC-3061 NSC3061 Pirimecidan Pirimetamin Pyrimethamin Tindurin Tinduring WRs 2978 WR-2978 WR2978 Chloridin
• Product Overview:
  Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR).{26927} By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg.{26925} Sulphonamides act synergistically with pyrimethamine by arresting production of dihydrofolic acid, resulting in the sequential blockade of the folate pathway of protozoa.{26897} Pyrimethamine has also been found to limit the expression of the superoxide dismutase 1 (SOD1) gene, a metalloenzyme involved in amyotrophic lateral sclerosis.{26926}