PX-478

PX-478

CAT N°: 10005189
Price:

From 99.00 84.15

PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1? in cancer cells, resulting in reduced expression of HIF-1? target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1? level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride
  • Correlated keywords
    • 685847-78-3 HIF1? HIF-1a HIF1a PX478 HCl
  • Product Overview:
    PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1? in cancer cells, resulting in reduced expression of HIF-1? target genes.{11835} It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1? level.{11835} PX-478 can also increase chemo- or radiosensitivity of tumors.{33612,33613}

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