PX-13-17OH

PX-13-17OH

CAT N°: 21203
Price:

From 85.00 72.25

PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3K?, PI3K?, PI3K?, and PI3K? (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione
  • Correlated keywords
    • PX1317OH PX13-17OH PX-1317OH PX-13-17-OH PX1317OH wortmannin PI3K PI-3K PI-3-K PI-3K ? ? ? ? S-6 6K U87-MG U-87MG 87
  • Product Overview:
    PX-13-17OH is a PI3K inhibitor.{18123} It selectively inhibits PI3K?, PI3K?, PI3K?, and PI3K? (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 µM). PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 µg/ml. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.

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