Purvalanol A

Purvalanol A

CAT N°: 14579
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From 48.00 40.80

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.{6960,14995} Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death.{22865} At 10 ?M, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.{22866}

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