Puromycin Amino<wbr/>nucleoside

Puromycin Aminonucleoside

CAT N°: 15509
Price:

From 92.00 78.20

Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 ?M, PANS affects glomerular epithelial cell adhesion, reducing ?3?1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3′-amino-3′-deoxy-N,N-dimethyl-adenosine
  • Correlated keywords
    • 28315-?29-?9 54833-?68-?0 136680-?68-?7 PANs antibiotics analogs glomerulosclerosis nephrosis proteinuria rats models nephrotoxin glomerular epithelial cells toxins renal diseases portions puromycin nephrin podocin NSCs 3056 NSC-3056 NSC3056 SAN stylomycin aminonucleoside
  • Product Overview:
    Puromycin (Item No. 13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.{21743} Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce apoptosis. Instead it is used to induce nephropathy in laboratory animal models to study focal and segmental glomerulosclerosis, the induction of nephrosis, and the events leading to proteinuria.{25326} When administered to rats at 0.5-5 ?M, PANS affects glomerular epithelial cell adhesion, reducing ?3?1 integrin expression.{25327} PANS also has been shown to decrease nephrin and podocin expression.{25325}

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