Purmorphamine

Purmorphamine

CAT N°: 10009634
Price:

From 43.00 36.55

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
  • Correlated keywords
    • stem cells differentiation osteoblasts osteogenesis osteoporosis bone smoothened hedgehog progenitor cells expression signalling pathways signaling transmembrane agonists receptors
  • Product Overview:
    Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.{14871,14873} The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.{14871} Investigation into purmorphamine’s mechanism of action indicates that it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.{14874,14872}

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