PTP Inhibitor II

PTP Inhibitor II

CAT N°: 20629

PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(?SH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 ?M, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Dangerous Good in said quantity, not available for sale.

  • Synonyms
    • 2-bromo-1-(4-methoxyphenyl)-ethanone
  • Correlated keywords
    • protein tyrosine SHP-1 SHP1 dSH2 1-(Bromoacetyl)-4-methoxybenzene 2-(4-Methoxyphenyl)-2-oxoethyl bromide 4-Methoxy-2′-bromoacetophenone Bromomethyl 4-methoxyphenyl ketone Bromomethyl p-anisyl ketone Bromomethyl p-methoxyphenyl NSC129010
  • Product Overview:
    PTP inhibitor II is a cell-permeable protein tyrosine phosphatase (PTP) inhibitor that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(?SH2)).{31401} PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Item No. 19766) with Ki values of 128 and 43 ?M, respectively.{31401} SHP-1 has known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research.{31658}

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