PtdIns-<wbr/>(4,5)-<wbr/>P<sub>2</sub> (1,2-<wbr/>dipalmitoyl) (ammonium salt)

PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)

CAT N°: 64924
Price:

94.00 79.90

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{243,8344} PtdIns-(4,5)-P2 incorporated into membrane lipids can bind to important proteins such as Group IV cPLA2 and PLC?1, enhancing their adherence to the membrane and increasing the rate of substrate hydrolysis.{6009} PtdIns-(4,5)-P2 can be further phosphorylated to give triphosphates such as PtdIns-(3,4,5)-P3. It can also be cleaved by PI-specific PLC to give inositol triphosphates. The diacyl glycerol and IP3 generated by this PLC-cleavage are also part of a complex biochemical and signal transduction cascade which has not been entirely elucidated. For some additional reading, please see references {8344}, {3239}, and {8672}.

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