PtdIns-(3,4,5)-P<sub>3</sub>-<wbr/>fluorescein (triethylammonium salt)

PtdIns-(3,4,5)-P3–fluorescein (triethylammonium salt)

CAT N°: 10010383
Price:

From 129.00 109.65

The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096,8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates an intricate signaling cascade that has been implicated in cancer.{12235} PtdIns-(3,4,5)-P3 fluorescein is a fluorescent probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-(1-octadecanoyl-fluorescein-2R-octanoylphosphatidyl)inositol-3,4,5-trisphosphate, heptatriethylammonium salt
  • Correlated keywords
    • PIPs PIP3-fluorescein fluorescent PI3K PTENs phosphatidylinositol phosphates phosphorylated kinases binding proteins PIPs
  • Product Overview:
    The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096,8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates an intricate signaling cascade that has been implicated in cancer.{12235} PtdIns-(3,4,5)-P3 fluorescein is a fluorescent probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

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