PtdIns-<wbr/>(3,4,5)-<wbr/>P<sub>3</sub> (1,2-<wbr/>dipalmitoyl) (sodium salt)

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

CAT N°: 64920
Price:

71.00 60.35

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{243,8344} PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin ? and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.{5241,8674} Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references {3239} and {8672}.

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