Prothionamide

Prothionamide

CAT N°: 16074
Price:

From 55.00 46.75

Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium.{26434} It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, the enoyl-acyl ACP reductase involved in mycolic acid biosynthesis, with a Ki value of 2 nM.{26434}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-propyl-4-pyridinecarbothioamide
  • Correlated keywords
    • thioamides drugs leprosy tuberculosis inhibitors antibacterial bactericidal M. tuberculosis mycobacterium M. leprae M. avium covalent adducts nicotinamides adenine dinucleotide inhibits inhibition mycobacteria mycobacterial InhA enoyl-acyl ACP reductase mycolic acids biosynthesis ektebin 9778 R.P. protionamid protionamide protionizina protion RP 9778 RP9778 RP-9778 TH 1321 TH1321 TH-1321 trevintix tuberex anti-bacterial anti bacterial
  • Product Overview:
    Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium.{26434} It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, the enoyl-acyl ACP reductase involved in mycolic acid biosynthesis, with a Ki value of 2 nM.{26434}

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