Prostaglandin F<sub>2?</sub> methyl ester

Prostaglandin F2? methyl ester

CAT N°: 16011
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48.00 40.80

Prostaglandin F2? methyl ester (PGF2? methyl ester) is an analog of PGF2? in which the C-1 carboxyl group has been esterified as the methyl ester. PGF2? methyl ester was one of the first PG esters shown to have ocular hypotensive activity.{8837} This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF2?. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF2?-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.{8837}

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