(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo–PDMP (hydrochloride)
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is...
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€80.00 €68.00
€80.00 €68.00
Prostaglandin F2? ethyl amide (PGF2?-NEt) is an analog of PGF2? in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.{8941} Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo,{8941} studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.{9311} PGF2?-NEt would be expected to show the typical intraocular effects of PGF2? free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 54130-36-8 |
| Molecular formula | C22H39NO4 |
| Smiles | O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O, O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O, O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O |
| Molecular weight | 381,6 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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