Prostaglandin F<sub>2?</sub> Ethanolamide

Prostaglandin F2? Ethanolamide

CAT N°: 16013
Price:

106.00 90.10

Prostaglandin F2? ethanolamide (PGF2?-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.{2415} AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.{5089,11045} PGF2?-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2?-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.{8671}

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