Prostaglandin D<sub>2</sub>

Prostaglandin D2

CAT N°: 12010
Price:

From 74.00 62.90

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.{416} PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as ?-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.{1349}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 9?,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
  • Correlated keywords
    • Vasodilation prostaglandins brain sleep platelets aggregation. H-PGDS synthases mast cells hematopoietic allergic allergy asthmatic anaphylaxis hypotension inhibits inhibitors inhibition beta-trace .beta.-trace b-trace neurochemistry
  • Product Overview:
    Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.{416} PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as ?-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.{1349}

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