€615.00 €522.75
The progesterone receptor is a ligand-dependent transcription factor and member of the nuclear steroid hormone receptor family encoded by PGR in humans.{54711} It is composed of a C-terminal ligand-binding domain, a central globular DNA-binding domain, and an intrinsically disordered N-terminal domain. It is expressed primarily in the CNS and female reproductive tissues, where it has roles in maintaining cognitive flexibility and reproductive biology, respectively, as well as in bone and the cardiovascular system.{54711,54712} Two active isoforms of the progesterone receptor, N-terminally truncated progesterone receptor A and full-length progesterone receptor B, are produced by transcription of PGR using two promoters, and function as an inhibitor and activator of transcription, respectively. The inactive progesterone receptor is localized to the cytosol and assembled into an inactive multiprotein chaperone complex, which is essential for maintaining the progesterone receptor in a ligand-binding competent state. Progesterone binding to the inactive progesterone receptor induces a conformational change, dissociation of chaperones, dimerization, and nuclear translocation, resulting in modulation of gene transcription. Progesterone receptor levels are increased in uterine leiomyoma tissue compared with normal myometrium in patients with uterine fibroids and progesterone receptor expression is associated with favorable overall survival and recurrence-free survival in patients with ovarian cancer.{54713,54714} Cayman’s Progesterone Receptor (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µl |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Host | Rabbit |
| Antigen | Peptide from the C-terminal region of the progesterone receptor |
| Clone | RM357 |
| Isotype | IgG |
| Application(s) | IHC, WB |
| Formulation | 100 µl of protein A-affinity purified monoclonal antibody |
| Custom code | 3822.19 |
| UNSPSC code | 12352203 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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