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Proadrenomedullin (N-20) (PAMP-20) is an endogenous peptide with hypotensive activity.{42628} It consists of the 20 N-terminal amino acids of proadrenomedullin and is found primarily in human adrenal medulla and pheochromocytoma tissue, with small amounts present in the heart, lung, liver, spleen, pancreas, kidney, small intestine, and cerebral cortex.{42629} PAMP-20 is an agonist of the G protein-coupled orphan receptor MRGPRX2 that inhibits forskolin-induced cAMP accumulation in CHO cells expressing the human receptor with an EC50 value of 251 nM.{42630} It inhibits catecholamine secretion and sodium and calcium influx induced by the acetylcholine receptor (AChR) agonist carbachol (Item No. 14486) in bovine adrenal medullary cells in vitro (IC50s = 1.6, 2.5, and 1 ?M, respectively).{42631} PAMP-20 induces a hypotensive response in anesthetized rats when administered at doses of 10, 20, and 50 nmol/kg by intravenous bolus injection.{42628} It also dose-dependently reduces systemic arterial and hindlimb perfusion pressure in anesthetized cats when injected intravenously or into the hindlimb perfusion circuit, respectively, indicating vasodilator activity.{42632}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C112H178N36O27 • XCF3COOH |
| Smiles | NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N[H])C)=O)=O)=O)CC(O)=O)=O)=O)C)=O)=O)=O)CC1=CC=CC=C1)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5)=O)C)=O)=O)=O)=O.OC(C(F)(F)F)=O |
| Molecular weight | 2460,8 |
| Custom code | 3504.00 |
| Formulation | A solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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