Umirolimus

Umirolimus

CAT N°: 23585
Price:

From 176.00 149.60

Umirolimus is a semisynthetic macrocyclic lactone and a derivative of rapamycin (Item No. 13346) that has immunosuppressive and anti-inflammatory effects.{36314} It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model, coronary stents containing umirolimus for localized delivery to the vessel wall reduced stenosis by 50% and led to less thickening of the vessel wall than a bare metal stent. Rapamycin, and likely its derivatives, binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Formulations containing umirolimus have been used in coronary stents for localized delivery to the vessel wall.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 42-O-(2-ethoxyethyl)-rapamycin
  • Correlated keywords
    • 944472-64-4 Ba-9 Ba9 biolimus A9 A-9 antiinflammatory G-1 IL2 FKBP-12 TRM986 TRM-986
  • Product Overview:
    Umirolimus is a semisynthetic macrocyclic lactone and a derivative of rapamycin (Item No. 13346) that has immunosuppressive and anti-inflammatory effects.{36314} It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model, coronary stents containing umirolimus for localized delivery to the vessel wall reduced stenosis by 50% and led to less thickening of the vessel wall than a bare metal stent. Rapamycin, and likely its derivatives, binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Formulations containing umirolimus have been used in coronary stents for localized delivery to the vessel wall.

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