4-hydroxy Atorvastatin lactone

4-hydroxy Atorvastatin lactone

CAT N°: 23358
Price:

598.00 508.30

4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin (Item No. 10493), an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.{18239,18240,18241,18235} Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin (Item No. 22575) and 2-hydroxy atorvastatin, which can be interconverted between their acid and lactone forms.{18239} Atorvastatin can itself be lactonized to atorvastatin lactone (Item No. 20951) then metabolized by CYP3A4 directly to 4-hydroxy atorvastatin lactone and 2-hydroxy atorvastatin lactone.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
  • Correlated keywords
    • 314059-11-5 HMGCoA hyper-cholesterolemia CYP-3A4 hydroxyatorvastatin coenzyme A CYP450
  • Product Overview:
    4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin (Item No. 10493), an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.{18239,18240,18241,18235} Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin (Item No. 22575) and 2-hydroxy atorvastatin, which can be interconverted between their acid and lactone forms.{18239} Atorvastatin can itself be lactonized to atorvastatin lactone (Item No. 20951) then metabolized by CYP3A4 directly to 4-hydroxy atorvastatin lactone and 2-hydroxy atorvastatin lactone.

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