RAD51 Inhibitor B02

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RAD51 Inhibitor B02

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Cat No: 22133

Biochemicals - Small Molecule Inhibitors

RAD51 inhibitor B02 is an inhibitor of RAD51 recombinase (IC50 = 27.4 µM in a FRET-based DNA strand exchange assay), which is often overexpressed in cancer cells.{41309} It is selective for RAD51 over the E. coli homologue RecA at concentrations up to...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

Correlated keywords:

488840-95-5 RAD-51 DSB BO-2

Product Overview:
RAD51 inhibitor B02 is an inhibitor of RAD51 recombinase (IC50 = 27.4 µM in a FRET-based DNA strand exchange assay), which is often overexpressed in cancer cells.{41309} It is selective for RAD51 over the E. coli homologue RecA at concentrations up to 250 µM and over RAD54 at concentrations up to 200 µM. RAD51 inhibitor B02 inhibits RAD51 binding to single-stranded DNA (ssDNA) and disrupts double-stranded DNA binding to the RAD51/ssDNA filament.{41310} It inhibits irradiation-induced RAD51 foci formation in HEK293 cells at a concentration of 50 µM. RAD51 inhibitor B02 increases sensitivity to cisplatin (Item No. 13119) in mouse embryonic fibroblasts in vitro and in an MDA-MB-231 mouse xenograft model when used at a dose of 50 mg/kg.{41311}

Size	5 mg
Shipping	dry ice
CAS Number	1290541-46-6
Molecular Formula	C₂₂H₁₇N₃O
SMILES	O=C1C2=CC=CC=C2N=C(/C=C/C3=CN=CC=C3)N1CC4=CC=CC=C4
Molecular Weight	339,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.