VH298

VH298

CAT N°: 21133
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From 55.00 46.75

VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL; Kd = 90 nM by isothermal titration calorimetry).{32855} VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-? (HIF-?) isoforms leading to proteasomal degradation. Through its effects on VHL, VH298 promotes the accumulation of HIF-? in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes.{32855}

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