VH298

VH298

CAT N°: 21133
Price:

From 55.00 46.75

VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL; Kd = 90 nM by isothermal titration calorimetry).{32855} VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-? (HIF-?) isoforms leading to proteasomal degradation. Through its effects on VHL, VH298 promotes the accumulation of HIF-? in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes.{32855}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • Correlated keywords
    • VH-298 HIF? HIF-a HIFa
  • Product Overview:
    VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL; Kd = 90 nM by isothermal titration calorimetry).{32855} VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-? (HIF-?) isoforms leading to proteasomal degradation. Through its effects on VHL, VH298 promotes the accumulation of HIF-? in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes.{32855}

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